Human Acylphosphatase 1 (ACYP1) Protein

Background

Acylphosphatase 1 (ACYP1) is a small cytosolic enzyme that catalyzes the hydrolysis of acyl-phosphate bonds in a variety of substrates, including 1,3-bisphosphoglycerate and carbamoyl phosphate. ACYP1 is primarily expressed in erythrocytes and the brain, where it is thought to play a role in maintaining energy homeostasis and regulating cellular metabolism. It may also influence signaling pathways by modulating the levels of phosphorylated intermediates. ACYP1 has been implicated in oxidative stress responses and apoptosis, as its dysregulation is associated with increased susceptibility to oxidative damage. Mutations or altered expression of ACYP1 may contribute to neurological disorders and metabolic diseases, though its precise physiological roles remain under investigation.