Human Acylglycerol Kinase (AGK) Protein

Este producto es parte de AGK - Acylglycerol Kinase:Acylglycerol kinase
Human Acylglycerol Kinase (AGK) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein AGK

proveedor

Abbexa

reference

abx650682

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human AGK Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Acylglycerol kinase (AGK) is a mitochondrial enzyme that catalyzes the phosphorylation of monoacylglycerol and diacylglycerol to produce lysophosphatidic acid (LPA) and phosphatidic acid (PA), which are critical intermediates in lipid metabolism, membrane biosynthesis, and intracellular signaling pathways. AGK also plays an essential role in the assembly and stability of mitochondrial respiratory chain supercomplexes, ensuring efficient oxidative phosphorylation and ATP production. This dual function underscores its importance in both energy metabolism and lipid signaling. Mutations in the AGK gene are associated with Sengers syndrome, a rare mitochondrial disorder characterized by cardiomyopathy, cataracts, skeletal myopathy, and lactic acidosis. Dysregulation of AGK has also been linked to cancer progression, where it enhances tumor growth by modulating lipid-derived signaling molecules and energy homeostasis. AGK is gaining attention as a therapeutic target in cancer and mitochondrial dysfunction, with research exploring its potential in restoring metabolic balance and energy efficiency.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Acylglycerol Kinase (AGK)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 61.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr15-Pro300 Tag: N-terminal His tag and GST tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

AGK


dry ice

No


availability

Shipped within 5-7 working days.


alias

CATC5,CTRCT38,MTDPS10,MULK


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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