Human Acylglycerol Kinase (AGK) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein AGK
proveedor
Abbexareference
abx650682Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human AGK Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
Acylglycerol kinase (AGK) is a mitochondrial enzyme that catalyzes the phosphorylation of monoacylglycerol and diacylglycerol to produce lysophosphatidic acid (LPA) and phosphatidic acid (PA), which are critical intermediates in lipid metabolism, membrane biosynthesis, and intracellular signaling pathways. AGK also plays an essential role in the assembly and stability of mitochondrial respiratory chain supercomplexes, ensuring efficient oxidative phosphorylation and ATP production. This dual function underscores its importance in both energy metabolism and lipid signaling. Mutations in the AGK gene are associated with Sengers syndrome, a rare mitochondrial disorder characterized by cardiomyopathy, cataracts, skeletal myopathy, and lactic acidosis. Dysregulation of AGK has also been linked to cancer progression, where it enhances tumor growth by modulating lipid-derived signaling molecules and energy homeostasis. AGK is gaining attention as a therapeutic target in cancer and mitochondrial dysfunction, with research exploring its potential in restoring metabolic balance and energy efficiency.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Acylglycerol Kinase (AGK)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 61.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr15-Pro300 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
AGK
dry ice
No
availability
Shipped within 5-7 working days.
alias
CATC5,CTRCT38,MTDPS10,MULK
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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