Human Activin A Receptor Type I (ACVR1) Protein

Este producto es parte de ACVR - Activin A Receptor Type
Human Activin A Receptor Type I (ACVR1) Protein
221€ (10 µg)

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Name
Human Activin A Receptor Type I (ACVR1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx065132
Tested Applications
WB, SDS-PAGE

Description

Human ACVR1 (ACVR1) is a recombinant Human protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Activin A Receptor Type I (ACVR1)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Ile208-Lys340
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Observed MW
Calculated MW: 16.7 kDa
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
Q04771
Alias
ACVRLK2
Background
Protein ACVR1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

ACVR1, also called ALK2 (Activin Receptor-Like Kinase 2), is a transmembrane serine/threonine kinase receptor. It binds ligands like BMPs (Bone Morphogenetic Proteins), initiating intracellular SMAD signaling. This receptor plays a crucial role in bone development, embryogenesis, and organogenesis. Mutations in ACVR1 are linked to fibrodysplasia ossificans progressiva (FOP), a rare disorder where soft tissues progressively ossify. Structurally, it comprises an extracellular ligand-binding domain, a single transmembrane helix, and an intracellular kinase domain.

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