Activin Receptor Type-1 (ACVR1) Antibody
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Descripción del producto
ACVR1 Antibody is a Rabbit Polyclonal Antibody against ACVR1.
Documents del producto
Especificaciones del producto
| NCBI Accession | NP_001096.1 |
| Alias | ACVRLK2 |
| Availability | Shipped within 5-10 working days. |
| Background | Antibody anti-ACVR1 |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Form | Liquid |
| Gene ID | 90 |
| Host | Rabbit |
| Immunogen Target | Activin Receptor Type-1 (ACVR1) |
| Isotype | IgG |
| Name | Activin Receptor Type-1 (ACVR1) Antibody |
| Note | Concentration: > 0.2 mg/ml - |
| Price | 195 |
| Provider | Abbexa |
| Purification | Purified by affinity chromatography. |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx007020 |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Tested Applications | ELISA, WB |
| UniProt ID | Q04771 |
Descripcion del producto en español
Background en español
ACVR1, also called ALK2 (Activin Receptor-Like Kinase 2), is a transmembrane serine/threonine kinase receptor. It binds ligands like BMPs (Bone Morphogenetic Proteins), initiating intracellular SMAD signaling. This receptor plays a crucial role in bone development, embryogenesis, and organogenesis. Mutations in ACVR1 are linked to fibrodysplasia ossificans progressiva (FOP), a rare disorder where soft tissues progressively ossify. Structurally, it comprises an extracellular ligand-binding domain, a single transmembrane helix, and an intracellular kinase domain.
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