Human Activin A Receptor Type 2B (ACVR2B) Protein (Active)

Este producto es parte de ACVR - Activin A Receptor Type
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585€ (100 µg)

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935106861
info@markelab.com
name
Human Activin A Receptor Type 2B (ACVR2B) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx691623
tested applications
SDS-PAGE

Description

Human ACVR2B Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the extracellular domain of human ACVR2B (NP_001097.2) (Met 1-Thr 134) was fused with a polyhistidine tag at the C-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
ACVR2B
Host
HEK293 cells
Origin
Human
Observed MW
Molecular Weight: 15 kDa

Sequence Fragment: Met1-Thr134

Tag: C-terminal His tag

Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 97% (SDS-PAGE)
Size 1
100 µg
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NP_001097.2
Alias
Activin receptor type IIB,ACTR-IIB
Background
Protein ACVR2B
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ACVR2B is another type II receptor involved in activin and myostatin signaling pathways. It phosphorylates type I receptors (e.g., ACVR1B) to activate SMAD-dependent signaling cascades. ACVR2B regulates processes like muscle growth, reproductive function, and embryonic development. Inhibition of ACVR2B has been explored as a therapeutic approach for muscle-wasting disorders, such as cachexia and muscular dystrophy. Mutations in ACVR2B can impair ligand-receptor interactions, leading to developmental defects.
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