Human Activin A Receptor Type 1C (ACVR1C) ELISA Kit

Este producto es parte de ACVR - Activin A Receptor Type
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715€ (96 tests)

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935106861
info@markelab.com
name
Human Activin A Receptor Type 1C (ACVR1C) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385610
tested applications
ELISA

Description

Human Activin A Receptor Type 1C (ACVR1C) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Activin A Receptor Type 1C (ACVR1C) concentrations in tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
ELISA Kits
Immunogen Target
Activin A Receptor Type 1C (ACVR1C)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.313 ng/ml - 20 ng/ml
Sensitivity
< 0.12 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Availability
Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q8NER5
Gene ID
130399
OMIM
608981
Alias
ACTR-IC,Activin receptor-like kinase 7 ,ALK-7
Background
Elisa kits for ACVR1C
Status
RUO
Note
Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.

This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ACVR1C, also known as ALK7 (Activin Receptor-Like Kinase 7), is a type I receptor in the TGF-β superfamily of signaling proteins. It is primarily activated by ligands such as activins (particularly Activin B) and Nodal. ACVR1C phosphorylates receptor-regulated SMADs, specifically SMAD2/3, which form complexes with SMAD4 to regulate gene transcription. ACVR1C plays critical roles in metabolic regulation, adipogenesis, pancreatic β-cell function, and embryonic development. It is predominantly expressed in tissues like the pancreas, adipose tissue, ovaries, and central nervous system. Dysregulation of ACVR1C has been linked to obesity, insulin resistance, and type 2 diabetes due to its role in fat cell differentiation and energy metabolism. Additionally, its signaling pathway is implicated in tumorigenesis, where it influences cell proliferation and survival.

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