ACVR1C antibody
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Name
ACVR1C antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab00130
Tested Applications
ELISA, WB, IHC
Description
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | activin A receptor, type IC (ACVR1C) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:100 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 60 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8NER5 |
| Gene ID | 130399 |
| Alias | ACTR-IC,Activin receptor-like kinase 7 ,ALK-7 |
| Background | Antibody anti-ACVR1C |
| Status | RUO |
| Note | Mol. Weight 60 kDa |
Background
ACVR1C, also known as ALK7 (Activin Receptor-Like Kinase 7), is a type I receptor in the TGF-β superfamily of signaling proteins. It is primarily activated by ligands such as activins (particularly Activin B) and Nodal. ACVR1C phosphorylates receptor-regulated SMADs, specifically SMAD2/3, which form complexes with SMAD4 to regulate gene transcription. ACVR1C plays critical roles in metabolic regulation, adipogenesis, pancreatic β-cell function, and embryonic development. It is predominantly expressed in tissues like the pancreas, adipose tissue, ovaries, and central nervous system. Dysregulation of ACVR1C has been linked to obesity, insulin resistance, and type 2 diabetes due to its role in fat cell differentiation and energy metabolism. Additionally, its signaling pathway is implicated in tumorigenesis, where it influences cell proliferation and survival.
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