Human Activator of Apoptosis Harakiri (HRK) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Activator of Apoptosis Harakiri (HRK) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx384988
tested applications
ELISA
Description
Human Activator of Apoptosis Harakiri (HRK) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human HRK concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Activator of Apoptosis Harakiri (HRK) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O00198 |
| Gene ID | 8739 |
| OMIM | 603447 |
| Alias | DP5,HARAKIRI,BID3,BH3-interacting domain-containing protein 3,Neuronal death protein DP5 |
| Background | Elisa kits for HRK |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Activator of apoptosis harakiri (HRK) is a pro-apoptotic protein that belongs to the Bcl-2 family of proteins, which regulate cell death by controlling mitochondrial outer membrane permeabilization HRK is involved in initiating apoptosis in response to cellular stress, including DNA damage, oxidative stress, and growth factor deprivation HRK interacts with anti-apoptotic proteins like Bcl-2 and Bcl-xL, promoting the release of apoptotic factors such as cytochrome c from the mitochondria, which activates caspases and leads to programmed cell death HRK is particularly important in neurons and immune cells, where it helps eliminate damaged or unwanted cells during development and in response to injury Dysregulation of HRK has been linked to various diseases, including cancer and neurodegenerative disorders, where loss of HRK expression allows cells to evade apoptosis and proliferate uncontrollably In cancer, HRK’s ability to promote cell death makes it a potential therapeutic target for inducing apoptosis in tumor cells
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