Human Actin-related protein 3 (ACTR3) Protein

Background

ACTR3 functions alongside ACTR2 as part of the ARP2/3 complex, driving actin filament branching and nucleation. Structurally, ACTR3 forms a dimer with ACTR2 to create a template for new filament growth. It plays a fundamental role in cytoskeletal remodeling processes, such as cell motility, intracellular trafficking, and immune cell function. ACTR3 is indispensable for processes like lamellipodia extension during cell migration. Mutations in ACTR3 are linked to developmental abnormalities, immune deficiencies, and impaired wound healing due to defective actin polymerization.