Human Actin Like 7A (ACTL7A) ELISA Kit
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Description
Human Actin Like 7A (ACTL7A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Actin Like Protein 7A (ACTL7A) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Actin Like 7A (ACTL7A) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.19 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9Y615 |
| Gene ID | 10881 |
| OMIM | 604303 |
| Alias | SPGF86 |
| Background | Elisa kits for ACTL7A |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ACTL7A is a testis-specific actin-like protein predominantly expressed during spermatogenesis. It shares structural homology with canonical actins, including an ATP/ADP-binding site critical for nucleotide interactions. However, ACTL7A does not polymerize into filaments and instead performs unique roles in germ cell cytoskeletal dynamics. It is involved in chromatin remodeling during spermatid maturation, assisting in nuclear shaping and acrosome biogenesis. ACTL7A expression is tightly regulated, and disruptions in its function can lead to male infertility due to defects in sperm morphology and motility.
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anti- ACTL7A antibody
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Actin Like 7A (ACTL7A) Antibody
ACTL7A is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. ACTL7A (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known.
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