Human Acetylcholinesterase Associated Protein (ACHAP) Protein
234€ (10 µg)
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name
Human Acetylcholinesterase Associated Protein (ACHAP) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166174
tested applications
WB, SDS-PAGE
Description
Acetylcholinesterase Associated Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Acetylcholinesterase Associated Protein (ACHAP) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 19.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg33-Pro179 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ACHAP,C6orf82 |
| Background | Protein CUTA |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The cutA divalent cation tolerance homolog (CUTA) is a highly conserved protein that plays a role in cellular tolerance to divalent metal cations, such as copper, zinc, and nickel. It is ubiquitously expressed in various tissues and is localized in both the cytoplasm and mitochondria, where it is thought to regulate metal ion homeostasis and protect cells from metal-induced toxicity. CUTA is implicated in modulating mitochondrial function and redox balance by ensuring appropriate cation levels, which are essential for enzymatic activities and structural stability within the organelle. Dysregulation of CUTA expression or function has been associated with mitochondrial dysfunction and oxidative stress, which are linked to neurodegenerative diseases, including Alzheimer's disease. CUTA has also been suggested to have a role in copper homeostasis, as it may influence copper-binding proteins and prevent copper-induced oxidative damage. Although its precise mechanisms of action remain under investigation, CUTA's involvement in metal ion detoxification and mitochondrial health makes it a potential target for understanding and treating conditions associated with metal ion imbalance.
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