Acetylcholinesterase Associated Protein (ACHAP) Antibody
286€ (100 µl)
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name
Acetylcholinesterase Associated Protein (ACHAP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx129202
tested applications
WB, IHC, IF/ICC
Description
Acetylcholinesterase Associated Protein Antibody is a Rabbit Polyclonal against Acetylcholinesterase Associated Protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acetylcholinesterase Associated Protein (ACHAP) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60888 |
| Alias | ACHAP,C6orf82 |
| Background | Antibody anti-CUTA |
| Status | RUO |
Descripción
The cutA divalent cation tolerance homolog (CUTA) is a highly conserved protein that plays a role in cellular tolerance to divalent metal cations, such as copper, zinc, and nickel. It is ubiquitously expressed in various tissues and is localized in both the cytoplasm and mitochondria, where it is thought to regulate metal ion homeostasis and protect cells from metal-induced toxicity. CUTA is implicated in modulating mitochondrial function and redox balance by ensuring appropriate cation levels, which are essential for enzymatic activities and structural stability within the organelle. Dysregulation of CUTA expression or function has been associated with mitochondrial dysfunction and oxidative stress, which are linked to neurodegenerative diseases, including Alzheimer's disease. CUTA has also been suggested to have a role in copper homeostasis, as it may influence copper-binding proteins and prevent copper-induced oxidative damage. Although its precise mechanisms of action remain under investigation, CUTA's involvement in metal ion detoxification and mitochondrial health makes it a potential target for understanding and treating conditions associated with metal ion imbalance.
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