Human Acetyl Coenzyme A Acyltransferase 1 (ACAA1) Protein
195€ (10 µg)
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name
Human Acetyl Coenzyme A Acyltransferase 1 (ACAA1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650410
tested applications
WB, SDS-PAGE
Description
Human ACAA1 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Acetyl Coenzyme A Acyltransferase 1 (ACAA1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 29.1 kDa Observed MW (SDS-PAGE): 29 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly182-Asn424 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09110 |
| Alias | ACAA, Lnc-Myd88, PTHIO, THIO |
| Background | Protein ACAA1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Acetyl Coenzyme A Acyltransferase 1 (ACAA1), also known as thiolase, is a peroxisomal enzyme involved in the final step of beta-oxidation of very-long-chain fatty acids and branched-chain fatty acids. It catalyzes the thiolytic cleavage of 3-ketoacyl-CoA into acetyl-CoA and a shortened acyl-CoA, which is then further metabolized for energy production. ACAA1 is critical for lipid metabolism and plays an important role in energy homeostasis during fasting or periods of high energy demand. Dysregulation of ACAA1 activity can lead to metabolic disorders, such as Zellweger syndrome and other peroxisomal biogenesis disorders, characterized by impaired fatty acid oxidation and accumulation of toxic lipid intermediates. ACAA1 is also being studied for its role in the metabolic reprogramming of cancer cells, where it contributes to lipid catabolism and tumor progression.
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