ACAA1 antibody
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935106861
info@markelab.com
name
ACAA1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00058
tested applications
ELISA, WB, IHC
Description
This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | acetyl-Coenzyme A acyltransferase 1 (ACAA1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 44 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P09110 |
| Gene ID | 30 |
| Alias | ACAA, Lnc-Myd88, PTHIO, THIO |
| Background | Antibody anti-ACAA1 |
| Status | RUO |
| Note | Mol. Weight 44 kDa |
Descripción
Acetyl Coenzyme A Acyltransferase 1 (ACAA1), also known as thiolase, is a peroxisomal enzyme involved in the final step of beta-oxidation of very-long-chain fatty acids and branched-chain fatty acids. It catalyzes the thiolytic cleavage of 3-ketoacyl-CoA into acetyl-CoA and a shortened acyl-CoA, which is then further metabolized for energy production. ACAA1 is critical for lipid metabolism and plays an important role in energy homeostasis during fasting or periods of high energy demand. Dysregulation of ACAA1 activity can lead to metabolic disorders, such as Zellweger syndrome and other peroxisomal biogenesis disorders, characterized by impaired fatty acid oxidation and accumulation of toxic lipid intermediates. ACAA1 is also being studied for its role in the metabolic reprogramming of cancer cells, where it contributes to lipid catabolism and tumor progression.
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ACAA1 antibody
This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants.
Ver Producto