Human Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) Protein
234€ (5 µg)
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name
Human Acetyl Coenzyme A Acetyltransferase 2 (ACAT2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx073281
tested applications
SDS-PAGE
Description
ACAT2 Protein is a recombinant enzyme.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Acetyl CoProtein A Acetyltransferase 2 (ACAT2) |
| Host | E. coli |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BWD1 |
| Alias | ACAT2,Sterol O-acyltransferase 2 |
| Background | Protein ACAT2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ACAT2 is a cytosolic enzyme that is primarily expressed in the liver and intestine and is responsible for the esterification of cholesterol with long-chain fatty acids to form cholesteryl esters, which are then incorporated into lipoproteins such as very-low-density lipoproteins (VLDL) and chylomicrons. Unlike ACAT1, which is involved in mitochondrial ketone metabolism, ACAT2 plays a pivotal role in cholesterol homeostasis and lipid transport. It is essential for the packaging of cholesterol for transport through the bloodstream and is therefore crucial for maintaining lipid balance. Dysregulation of ACAT2 activity is associated with hypercholesterolemia and atherosclerosis, as increased cholesteryl ester formation can contribute to the formation of atherosclerotic plaques. Targeting ACAT2 has been explored as a potential therapeutic approach for reducing cholesterol levels and cardiovascular disease risk.
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