Human ABCG2 (ATP-binding cassette sub-family G member 2) ELISA Kit
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human ABCG2 (ATP-binding cassette sub-family G member 2) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH1095
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | Q9UNQ0 |
| Alias | ABC15,ABCP BCRP,BCRP1 BMDP,CD338,CDw338 |
| Background | Elisa kits for ABCG2 |
| Status | RUO |
Background
ABCG2, also known as the breast cancer resistance protein (BCRP), is a well-characterized ATP-binding cassette transporter involved in drug efflux and xenobiotic clearance. It is highly expressed in barrier tissues such as the intestine, liver, kidneys, and blood-brain barrier, where it protects cells by exporting a wide range of substrates, including drugs, toxins, and endogenous metabolites. ABCG2 plays a pivotal role in pharmacokinetics, influencing drug absorption, distribution, and elimination. It is also critical in stem cell biology, where it acts as a marker for side population cells due to its role in drug resistance and dye efflux. Overexpression of ABCG2 is a major contributor to multidrug resistance in cancer, as it actively pumps chemotherapeutic agents out of tumor cells, reducing their efficacy. Structurally, ABCG2 is a half-transporter that forms functional homodimers to mediate ATP-driven substrate transport. Dysregulation of ABCG2 has been linked to diseases such as gout and certain cancers, making it a target of interest in oncology and pharmacology.
Productos relacionados
Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) Antibody
ABCG2 Antibody is a Rabbit Polyclonal Antibody against ABCG2.…
Ver producto
Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) Antibody
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transp…
Ver producto
Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) Antibody
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transp…
Ver producto