Human ABCC4 (Multidrug resistance-associated protein 4) ELISA Kit
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Name
Human ABCC4 (Multidrug resistance-associated protein 4) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH1167
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 1.563-100ng/ml |
| Sensitivity | 0.938ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | O15439 |
| Alias | MOAT-B,MOATB,MRP4,Multidrug resistance-associated protein 4 |
| Background | Elisa kits for ABCC4 |
| Status | RUO |
Background
ABCC4, also known as multidrug resistance-associated protein 4 (MRP4), is an ATP-binding cassette transporter expressed in various tissues, including the liver, kidneys, and endothelial cells of the blood-brain barrier. It exports a wide range of substrates, including cyclic nucleotides, prostaglandins, antiviral drugs, and chemotherapeutic agents, from cells. ABCC4’s activity plays a critical role in cellular signaling by regulating intracellular levels of cyclic AMP and GMP. It is also involved in drug resistance, where its overexpression limits the intracellular accumulation of therapeutic agents. ABCC4 is upregulated in response to oxidative stress and inflammation, highlighting its role in protecting cells from toxic insults. Its diverse substrate specificity and involvement in drug efflux make ABCC4 a significant target in pharmacological research and disease management.
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