Human ABCA7 Protein

Este producto es parte de ABCA7 - ATP Binding Cassette Transporter A7
Human ABCA7 Protein

Pida mas información

935106861

info@markelab.com

Precio

260€ (10 µg)

Protein ABCA7

proveedor

Abbexa

reference

abx650882

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human ABCA7 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

ABCA7 (ATP-binding cassette subfamily A member 7) is a member of the ABC transporter family, which is responsible for the translocation of various substrates across membranes in an ATP-dependent manner. ABCA7 is primarily known for its role in lipid homeostasis and phagocytosis, and its genetic associations with neurodegenerative diseases, particularly Alzheimer's disease, have attracted significant scientific interest.ABCA7 is expressed in various tissues, including the brain, liver, spleen, and bone marrow, with particularly high levels in the central nervous system and immune cells. This distribution suggests its dual role in maintaining neuronal integrity and immune responses. ABCA7's function is closely related to lipid transport, particularly in regulating cellular cholesterol and phospholipid efflux. Emerging evidence also indicates its involvement in amyloid precursor protein (APP) processing and amyloid-beta peptide clearance, key mechanisms in Alzheimer's pathology. The gene encoding ABCA7, located on chromosome 19p13.3, has been a focus of genetic studies, revealing that mutations and polymorphisms can influence susceptibility to Alzheimer’s disease. Beyond neurodegeneration, ABCA7 may also play roles in immune regulation, inflammation, and other lipid-related disorders.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

ABCA7


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 51.0 kDa Observed MW (SDS-PAGE): 51.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu53-Leu249 Tag: N-terminal His tag and GST tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ABCA7


dry ice

No


availability

Shipped within 5-7 working days.


alias

ABCA-SSN,ABCX,AD9,Macrophage ABC transporter


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


Quizá le pueda interesar

Human ABCA7(ATP-binding cassette sub-family A member 7) ELISA Kit

Human ABCA7(ATP-binding cassette sub-family A member 7) ELISA Kit

proveedor

FineTest

reference

EH1708

reactivity

human

status

RUO

Precio a consultar

Ver más

Mouse Abca7(ATP-binding cassette sub-family A member 7) ELISA Kit

Mouse Abca7(ATP-binding cassette sub-family A member 7) ELISA Kit

proveedor

FineTest

reference

EM0635

reactivity

mouse

status

RUO

Precio a consultar

Ver más

anti- ABCA7 antibody

anti- ABCA7 antibody

proveedor

FineTest

reference

FNab00028

Tested Applications

ELISA, WB

reactivity

human,mouse

status

RUO

clonality

polyclonal

Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated ...

Precio a consultar

Ver más