Human ABCA7 Protein
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935106861
info@markelab.com
Precio
260€ (10 µg)
Protein ABCA7
proveedor
Abbexareference
abx650882Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human ABCA7 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
ABCA7 (ATP-binding cassette subfamily A member 7) is a member of the ABC transporter family, which is responsible for the translocation of various substrates across membranes in an ATP-dependent manner. ABCA7 is primarily known for its role in lipid homeostasis and phagocytosis, and its genetic associations with neurodegenerative diseases, particularly Alzheimer's disease, have attracted significant scientific interest.ABCA7 is expressed in various tissues, including the brain, liver, spleen, and bone marrow, with particularly high levels in the central nervous system and immune cells. This distribution suggests its dual role in maintaining neuronal integrity and immune responses. ABCA7's function is closely related to lipid transport, particularly in regulating cellular cholesterol and phospholipid efflux. Emerging evidence also indicates its involvement in amyloid precursor protein (APP) processing and amyloid-beta peptide clearance, key mechanisms in Alzheimer's pathology. The gene encoding ABCA7, located on chromosome 19p13.3, has been a focus of genetic studies, revealing that mutations and polymorphisms can influence susceptibility to Alzheimer’s disease. Beyond neurodegeneration, ABCA7 may also play roles in immune regulation, inflammation, and other lipid-related disorders.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
ABCA7
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 51.0 kDa Observed MW (SDS-PAGE): 51.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu53-Leu249 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ABCA7
dry ice
No
availability
Shipped within 5-7 working days.
alias
ABCA-SSN,ABCX,AD9,Macrophage ABC transporter
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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