Human ABCA7 Protein

Product specifications

Proteins and Peptides

ABCA7

E. coli

Human

Unconjugated

Molecular Weight: Calculated MW: 51.0 kDa  Observed MW (SDS-PAGE): 51.0 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Glu53-Leu249

Tag: N-terminal His tag and GST tag

Recombinant

> 90%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

Q8IZY2

ABCA-SSN,ABCX,AD9,Macrophage ABC transporter

Protein ABCA7

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ABCA7 (ATP-binding cassette subfamily A member 7) is a member of the ABC transporter family, which is responsible for the translocation of various substrates across membranes in an ATP-dependent manner. ABCA7 is primarily known for its role in lipid homeostasis and phagocytosis, and its genetic associations with neurodegenerative diseases, particularly Alzheimer's disease, have attracted significant scientific interest.ABCA7 is expressed in various tissues, including the brain, liver, spleen, and bone marrow, with particularly high levels in the central nervous system and immune cells. This distribution suggests its dual role in maintaining neuronal integrity and immune responses. ABCA7's function is closely related to lipid transport, particularly in regulating cellular cholesterol and phospholipid efflux. Emerging evidence also indicates its involvement in amyloid precursor protein (APP) processing and amyloid-beta peptide clearance, key mechanisms in Alzheimer's pathology. The gene encoding ABCA7, located on chromosome 19p13.3, has been a focus of genetic studies, revealing that mutations and polymorphisms can influence susceptibility to Alzheimer’s disease. Beyond neurodegeneration, ABCA7 may also play roles in immune regulation, inflammation, and other lipid-related disorders.

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