ATP-Binding Cassette Sub-Family A Member 7 (ABCA7) Antibody

Product specifications

Primary Antibodies

ATP-Binding Cassette Sub-Family A Member 7 (ABCA7)

Rabbit

Human, Mouse

WB: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

≥ 95% (SDS-PAGE)

Purified by immunogen affinity chromatography.

100 µg

Liquid

ELISA, WB

PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.

Shipped within 5-12 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q8IZY2

ABCA-SSN,ABCX,AD9,Macrophage ABC transporter

Antibody anti-ABCA7

RUO

Concentration: 2 mg/ml - Validity: 12 months.

Descripción

ABCA7 (ATP-binding cassette subfamily A member 7) is a member of the ABC transporter family, which is responsible for the translocation of various substrates across membranes in an ATP-dependent manner. ABCA7 is primarily known for its role in lipid homeostasis and phagocytosis, and its genetic associations with neurodegenerative diseases, particularly Alzheimer's disease, have attracted significant scientific interest.ABCA7 is expressed in various tissues, including the brain, liver, spleen, and bone marrow, with particularly high levels in the central nervous system and immune cells. This distribution suggests its dual role in maintaining neuronal integrity and immune responses. ABCA7's function is closely related to lipid transport, particularly in regulating cellular cholesterol and phospholipid efflux. Emerging evidence also indicates its involvement in amyloid precursor protein (APP) processing and amyloid-beta peptide clearance, key mechanisms in Alzheimer's pathology. The gene encoding ABCA7, located on chromosome 19p13.3, has been a focus of genetic studies, revealing that mutations and polymorphisms can influence susceptibility to Alzheimer’s disease. Beyond neurodegeneration, ABCA7 may also play roles in immune regulation, inflammation, and other lipid-related disorders.

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