Human A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) ELISA Kit
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Description
Human A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human A Kinase Anchor Protein 10 (AKAP10) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.19 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O43572 |
| Gene ID | 11216 |
| OMIM | 115080 |
| Alias | AKAP-10,D-AKAP-2,D-AKAP2,PRKA10 |
| Background | Elisa kits for AKAP10 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AKAP10, also known as dual-specific AKAP2 (D-AKAP2), is a dual-targeting scaffold protein that binds to PKA and other signaling proteins at cellular membranes, including mitochondria and plasma membranes. AKAP10 regulates PKA signaling in pathways related to cardiac function, mitochondrial biogenesis, and cellular energy metabolism. Polymorphisms in AKAP10, such as the I646V variant, are associated with altered heart rate, reduced heart rate variability, and an increased risk of arrhythmias, highlighting its importance in cardiovascular homeostasis. AKAP10 also interacts with mitochondrial proteins to regulate energy production, enhancing ATP synthesis and oxidative phosphorylation. AKAP10 has been implicated in apoptosis, where its role in PKA-dependent signaling ensures mitochondrial integrity during cellular stress. Additionally, AKAP10 participates in cell migration and polarity by organizing signaling complexes near the plasma membrane, influencing cytoskeletal reorganization and adhesion dynamics in cancer metastasis.
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