Human A Disintegrin And Metalloproteinase With Thrombospondin 9 (ADAMTS9) Protein

Background

ADAMTS9 (A Disintegrin And Metalloproteinase with Thrombospondin Motifs 9) is a member of the ADAMTS family of proteases. Like other members of the ADAMTS family, ADAMTS9 contains characteristic domains, including a metalloproteinase domain, a disintegrin-like domain, and thrombospondin type-1 (TSP-1) motifs. ADAMTS9 is expressed in various tissues, including the brain, heart, kidney, cartilage, and skeletal muscle. Its expression pattern suggests potential roles in tissue development, maintenance, and remodeling.ADAMTS9 is involved in various physiological processes, particularly in extracellular matrix (ECM) remodeling. It plays a role in the turnover and organization of ECM components, such as proteoglycans and collagens. Additionally, ADAMTS9 has been implicated in angiogenesis, wound healing, and inflammation.Dysregulation of ADAMTS9 has been associated with several diseases and conditions. For instance, ADAMTS9 has been linked to cancer, where it may affect tumor growth, invasion, and metastasis by influencing the ECM and angiogenesis. Moreover, mutations in the ADAMTS9 gene have been associated with certain developmental disorders and connective tissue diseases.