Human A Disintegrin And Metalloproteinase With Thrombospondin 16 (ADAMTS16) Protein
221€ (10 µg)
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935106861
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name
Human A Disintegrin And Metalloproteinase With Thrombospondin 16 (ADAMTS16) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166708
tested applications
WB, SDS-PAGE
Description
ADAMTS16 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | A Disintegrin And Metalloproteinase With Thrombospondin 16 (ADAMTS16) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 42.6 kDa Observed MW (SDS-PAGE): 43 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu290-Pro641 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8TE57 |
| Alias | Type 1 Motif 16,ADAMTS16s,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 16,ADAMTS-16,ADAM-TS16 |
| Background | Protein ADAMTS16 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ADAMTS16 (ADAM metallopeptidase with thrombospondin type 1 motif 16) is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS16 contains several characteristic domains of the ADAMTS family, including a signal peptide, a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and multiple thrombospondin type 1 (TSP1) motifs. ADAMTS16 is expressed in various tissues during development and in adulthood. It is found in tissues such as the heart, lungs, kidneys, and skeletal tissues.It may play a role in processes such as chondrogenesis and osteogenesis where it regulates ECM composition and structure. ADAMTS16 expression levels have been found to be dysregulated in various cancers, including breast cancer, ovarian cancer, and prostate cancer. Its roles in ECM remodeling and tissue development suggest potential contributions to tumor progression, invasion, and metastasis. Dysregulation of ADAMTS16 activity has been associated with musculoskeletal disorders such as osteoarthritis and intervertebral disc degeneration. In these conditions, ADAMTS16 contributes to the degradation of ECM components within cartilage and intervertebral discs, leading to tissue degeneration and joint dysfunction.
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