Human 5'-Nucleotidase / CD73 (NT5E) Protein

Este producto es parte de NT5E - 5'-nucleotidase ecto
Human 5'-Nucleotidase / CD73 (NT5E) Protein

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935106861

info@markelab.com

Precio

637€ (50 µg)

Protein NT5E

proveedor

Abbexa

reference

abx651291

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

5'-Nucleotidase, Ecto (NT5E) Protein (Active) is an active protein from Human.


Background

The NT5E gene encodes 5'-nucleotidase ecto, also known as CD73, a glycosylphosphatidylinositol (GPI)-anchored enzyme that is crucial in purinergic signaling. It catalyzes the hydrolysis of extracellular nucleotides into nucleosides, with a primary function of converting AMP (adenosine monophosphate) to adenosine. CD73 is expressed on a wide range of cell types, including endothelial cells, epithelial cells, fibroblasts, T cells, and tumor cells. It plays a fundamental role in regulating inflammation, vascular permeability, immune response, and tissue protection under stress conditions such as ischemia. Adenosine generated by CD73 is a potent signaling molecule that binds to adenosine receptors (A1, A2A, A2B, and A3) to mediate various physiological processes, including anti-inflammatory effects, vasodilation, and immunosuppression. In the immune system, CD73 suppresses pro-inflammatory responses and helps in the resolution of inflammation. This dual role makes NT5E a key molecule in both health and disease, especially in pathologies such as cancer, cardiovascular diseases, and chronic inflammatory disorders.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

5'-Nucleotidase / CD73 (NT5E)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

50 µg


size 2

100 µg


size 3

200 µg


size 4

500 µg


size 5

1 mg


observerd MW

Molecular Weight: Calculated MW: 53.6 kDa Observed MW: 53 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu29-Thr500 Tag: N-terminal His tag


purity

> 90%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

NT5E


dry ice

No


availability

Shipped within 5-7 working days.


alias

NT,En,NT5,NTE,eNT,CD73,E5NT,CALJA,5'-NT,5'-deoxynucleotidase,Ecto-5'-nucleotidase,IMP-specific 5'-nucleotidase,Thymidylate 5'-phosphatase 


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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clonality

polyclonal

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