Human 5-Hydroxytryptamine Receptor 4 / 5-HT4 (HTR4) Protein

Este producto es parte de HTR - 5-Hydroxytryptamine receptors
Human 5-Hydroxytryptamine Receptor 4 / 5-HT4 (HTR4) Protein

Pida mas información

935106861

info@markelab.com

Precio

2062.5€ (1 mg)

Protein HTR4

proveedor

Abbexa

reference

abx652347

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human 5-Hydroxytryptamine Receptor 4 (HTR4) Protein is a Recombinant Human protein expressed in E. coli.


Background

HTR4 is a G protein-coupled receptor (GPCR) that mediates the effects of serotonin (5-HT) through adenylate cyclase activation, increasing intracellular levels of cyclic AMP (cAMP). This receptor is widely expressed in the central nervous system, gastrointestinal tract, cardiovascular system, and urinary tissues, where it regulates processes such as memory, learning, mood modulation, peristalsis, and heart function. In the brain, HTR4 is particularly abundant in the hippocampus, cortex, and basal ganglia, contributing to cognitive function and mood stabilization. Activation of HTR4 receptors has anxiolytic and antidepressant effects, making it a promising target for mood disorders, including depression and anxiety. In the gastrointestinal system, HTR4 enhances motility by stimulating enteric neurons, leading to its therapeutic use in treating gastroesophageal reflux disease (GERD) and constipation. Research suggests that HTR4 plays a role in neurodegenerative diseases such as Alzheimer's disease due to its influence on acetylcholine release, promoting synaptic plasticity. Its pharmacological significance extends to therapies aimed at enhancing cognitive function, improving GI motility, and alleviating mood disorders.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

5-Hydroxytryptamine Receptor 4 / 5-HT4 (HTR4)


host

E. coli


conjugation

Unconjugated


form

Lyophilized


tested applications

WB, SDS-PAGE


size 1

1 mg


size 2

5 mg


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

HTR4


dry ice

No


availability

Shipped within 1-2 months.


alias

HTR4,5-HT4, 5-HT4R,5-HT4 receptor


note

This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.


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