Human 5-Hydroxytryptamine Receptor 4 / 5-HT4 (HTR4) Protein
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935106861
info@markelab.com
Precio
2062.5€ (1 mg)
Protein HTR4
proveedor
Abbexareference
abx652347Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human 5-Hydroxytryptamine Receptor 4 (HTR4) Protein is a Recombinant Human protein expressed in E. coli.
Background
HTR4 is a G protein-coupled receptor (GPCR) that mediates the effects of serotonin (5-HT) through adenylate cyclase activation, increasing intracellular levels of cyclic AMP (cAMP). This receptor is widely expressed in the central nervous system, gastrointestinal tract, cardiovascular system, and urinary tissues, where it regulates processes such as memory, learning, mood modulation, peristalsis, and heart function. In the brain, HTR4 is particularly abundant in the hippocampus, cortex, and basal ganglia, contributing to cognitive function and mood stabilization. Activation of HTR4 receptors has anxiolytic and antidepressant effects, making it a promising target for mood disorders, including depression and anxiety. In the gastrointestinal system, HTR4 enhances motility by stimulating enteric neurons, leading to its therapeutic use in treating gastroesophageal reflux disease (GERD) and constipation. Research suggests that HTR4 plays a role in neurodegenerative diseases such as Alzheimer's disease due to its influence on acetylcholine release, promoting synaptic plasticity. Its pharmacological significance extends to therapies aimed at enhancing cognitive function, improving GI motility, and alleviating mood disorders.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
5-Hydroxytryptamine Receptor 4 / 5-HT4 (HTR4)
host
E. coli
conjugation
Unconjugated
form
Lyophilized
tested applications
WB, SDS-PAGE
size 1
1 mg
size 2
5 mg
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
HTR4
dry ice
No
availability
Shipped within 1-2 months.
alias
HTR4,5-HT4, 5-HT4R,5-HT4 receptor
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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