Human 5-hydroxytryptamine receptor 2C (HTR2C) ELISA Kit
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Description
Human 5-hydroxytryptamine receptor 2C (HTR2C) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human 5-hydroxytryptamine receptor 2C (HTR2C) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | 5-hydroxytryptamine receptor 2C (HTR2C) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P28335 |
| Gene ID | 3358 |
| OMIM | 312861 |
| Alias | HTR2C,HTR1C, 5-HT1C, 5-HT2C, 5HTR2C, 5-HTR2C,5-HT2C receptor |
| Background | Elisa kits for HTR2C |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
HTR2C is a serotonin receptor subtype located primarily in the central nervous system (CNS), particularly in the hypothalamus, choroid plexus, and limbic regions, where it regulates mood, appetite, and metabolic processes. As a G protein-coupled receptor (GPCR), HTR2C exerts its effects by activating intracellular signaling cascades, including the phospholipase C pathway. HTR2C plays a critical role in energy homeostasis and appetite suppression, contributing to its regulation of body weight. Agonism of HTR2C receptors promotes the release of pro-opiomelanocortin (POMC) in hypothalamic neurons, leading to reduced food intake and increased energy expenditure. Drugs such as lorcaserin, a selective HTR2C agonist, have been used to treat obesity by reducing appetite. HTR2C is also implicated in neuropsychiatric disorders, including depression, anxiety, schizophrenia, and substance abuse. Genetic polymorphisms and dysfunction in HTR2C signaling have been linked to metabolic syndrome, antipsychotic-induced weight gain, and insulin resistance, particularly in patients undergoing psychiatric treatments. Furthermore, HTR2C modulates dopaminergic and noradrenergic systems, which play roles in motivation, reward, and mood regulation. Its influence on behaviors such as impulsivity, cognition, and stress responses makes HTR2C a significant target for obesity management, mood stabilization, and substance use disorders. Understanding the therapeutic modulation of HTR2C holds promise for treating both metabolic and psychiatric conditions.
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