Human 5-Hydroxytryptamine Receptor 2A / 5-HT2A (HTR2A) Protein

Este producto es parte de HTR - 5-Hydroxytryptamine receptors
Product Graph
2145€ (1 mg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Human 5-Hydroxytryptamine Receptor 2A / 5-HT2A (HTR2A) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652345
tested applications
WB, SDS-PAGE

Description

Human 5-Hydroxytryptamine Receptor 2A (HTR2A) Protein is a Recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
5-Hydroxytryptamine Receptor 2A / 5-HT2A (HTR2A)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Please enquire.
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
1 mg
Size 2
5 mg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 1-2 months.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
HTR2A,HTR2, 5-HT2A,5-HT2A receptor
Background
Protein HTR2A
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

HTR2A is a G protein-coupled receptor (GPCR) that mediates the actions of serotonin (5-HT), a neurotransmitter crucial for mood regulation, perception, and cognition. It is widely expressed in the central nervous system (CNS), particularly in the prefrontal cortex, hippocampus, and amygdala, regions involved in executive function, emotion, and learning. HTR2A is highly implicated in neuropsychiatric conditions, including schizophrenia, depression, anxiety, and mood disorders. Its activation influences intracellular calcium signaling and downstream pathways such as the phospholipase C cascade. HTR2A also interacts with various neurotransmitter systems, including dopamine, glutamate, and norepinephrine, which are critical for regulating mood and behavior. Importantly, many antipsychotic drugs, such as risperidone and clozapine, function as antagonists of HTR2A, improving symptoms of psychosis and mood stabilization. It is also the principal target for psychedelic compounds, like LSD and psilocybin, which bind to HTR2A and induce altered perceptions and consciousness. Genetic polymorphisms in the HTR2A gene have been associated with an increased risk of major depressive disorder and resistance to antidepressant therapy. Understanding HTR2A's role in serotonin signaling, mood regulation, and cognitive processes makes it a crucial target for pharmacological intervention in a range of psychiatric and neurodevelopmental disorders.

Related Products

EH13901

Human HTR2A (5-hydroxytryptamine receptor 2A) ELISA Kit

Ver Producto
ER2149

Rat HTR2A (5-hydroxytryptamine receptor 2A) ELISA Kit

Ver Producto
FNab10872

HTR2A antibody

Ver Producto