Human 4-Aminobutyrate Aminotransferase (ABAT) Protein

Product specifications

Proteins and Peptides

4-Aminobutyrate Aminotransferase (ABAT)

E. coli

Human

Unconjugated

Molecular Weight: Calculated MW: 32.4 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Pro249-Lys500
Tag: N-terminal His tag

Recombinant

> 90%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

P80404

GABA-AT,GABAT,NPD009,GABA transaminase

Protein ABAT

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

4-Aminobutyrate Aminotransferase (ABAT), also known as GABA transaminase, is a mitochondrial enzyme that plays a crucial role in the metabolism of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. ABAT catalyzes the conversion of GABA to succinic semialdehyde, which is subsequently converted to succinate and enters the tricarboxylic acid (TCA) cycle, linking GABA metabolism to energy production. This process is critical for maintaining GABAergic tone and neurotransmitter balance in the brain. Dysregulation of ABAT activity has been implicated in neurological and psychiatric disorders, including epilepsy, anxiety, depression, and schizophrenia, where altered GABA levels contribute to pathophysiology. Mutations in the ABAT gene can result in disorders such as GABA-transaminase deficiency, characterized by severe developmental delays, seizures, and hypotonia. ABAT is also a target for anticonvulsant drugs like vigabatrin, which inhibit its activity to increase GABA levels and reduce neuronal excitability. Beyond its role in the nervous system, ABAT has emerging significance in cancer biology, as its expression is altered in certain tumors, influencing metabolic pathways and tumor progression.

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anti- ABAT antibody

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

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4-Aminobutyrate Aminotransferase (ABAT) Antibody

ABAT Antibody is a Rabbit Polyclonal antibody against ABAT. 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

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4-Aminobutyrate Aminotransferase (ABAT) Antibody

4-Aminobutyrate Aminotransferase Antibody is a Rabbit Polyclonal antibody against 4-Aminobutyrate Aminotransferase.

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