Human 14-3-3 Protein Eta (YWHAH) Protein
1235€ (100 µg)
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935106861
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name
Human 14-3-3 Protein Eta (YWHAH) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693162
tested applications
SDS-PAGE
Description
Human 14-3-3 Protein Eta (YWHAH) Protein is a recombinant protein kinase.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | 14-3-3 Protein Eta (YWHAH) |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: 55 kDa Sequence Fragment: Gly2-Asn246 Tag: N-terminal GST tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 20mM Tris, 0.15M NaCl, 20mM GST, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q04917 |
| Alias | YWHAH, YWHA1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta |
| Background | Protein YWHAH |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
YWHAH, a member of the 14-3-3 protein family, acts as an adaptor molecule that binds phosphorylated serine/threonine residues on target proteins, regulating their stability, localization, and function. YWHAH is highly expressed in the brain, where it is involved in synaptic plasticity, neurotransmitter release, and neuronal development. It interacts with key signaling molecules in pathways such as MAPK, PI3K/Akt, and dopamine receptor signaling, influencing cellular processes like survival, growth, and stress response. Dysregulation of YWHAH is associated with neurological disorders such as schizophrenia, Parkinson’s disease, and rheumatoid arthritis, where altered signaling contributes to disease pathogenesis. Elevated levels of YWHAH have been detected in autoimmune diseases, highlighting its role as a biomarker. Knockout studies demonstrate impaired synaptic transmission, defects in neuronal signaling, and altered stress adaptation, emphasizing its importance in brain function, neurodevelopment, and immune regulation.
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