HSPG2-Specific Antibody

Background

Heparan sulfate proteoglycan 2 (HSPG2), also known as perlecan, is a significant component of the extracellular matrix (ECM) in many tissues, including basement membranes. HSPG2 plays a crucial role in various physiological processes such as cell adhesion, proliferation, differentiation, and migration. It is synthesized as a large multidomain protein and is extensively glycosylated. Perlecan is ubiquitous in the body, present in vascular endothelial cells, the central nervous system, skeletal muscle, and other tissues. Its importance is underscored by its involvement in numerous developmental and pathological conditions, including cancer, cardiovascular diseases, and genetic disorders like Schwartz-Jampel syndrome and Dyssegmental Dysplasia Silverman-Handmaker type.