HLA Class II Histocompatibility Antigen Gamma Chain (CD74) Antibody (PerCP)
637€ (100 µg)
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935106861
info@markelab.com
name
HLA Class II Histocompatibility Antigen Gamma Chain (CD74) Antibody (PerCP)
category
Primary Antibodies
provider
Abbexa
reference
abx444034
tested applications
WB, FCM, FACS
Description
CD74 Antibody is a Mouse Monoclonal against CD74.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | HLA Class II Histocompatibility Antigen Gamma Chain (CD74) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, FACS: 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | PerCP |
| Isotype | IgG1 |
| Purification | Purified by Protein G. |
| Size 1 | 100 µg |
| Tested Applications | WB, FCM, FACS |
| Buffer | PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04233 |
| Gene ID | 972 |
| NCBI Accession | NP_001020329.1 |
| Alias | p33,CLIP,DHLAG,HLADG,Ia-GAMMA,HLA class II histocompatibility antigen gamma chain,HLA-DR antigens-associated invariant chain,Ia antigen-associated invariant chain (Ii) |
| Background | Antibody anti-CD74 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
CD74, also known as the invariant chain (Ii), is a type II transmembrane glycoprotein that plays a critical role in the immune system, particularly in antigen processing and presentation. CD74 is encoded by the CD74 gene and is primarily expressed on antigen-presenting cells (APCs) such as B cells, dendritic cells, and macrophages, although it is also found on some non-immune cells, including certain epithelial and cancer cells. One of its central functions is to act as a chaperone for major histocompatibility complex class II (MHC-II) molecules, ensuring the proper folding, trafficking, and peptide loading of MHC-II, which is essential for the presentation of antigens to CD4+ T cells. In addition to its role in antigen presentation, CD74 also functions as a receptor for macrophage migration inhibitory factor (MIF), which modulates inflammatory responses and cell survival pathways.
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