HLA Class II Histocompatibility Antigen Gamma Chain (CD74) Antibody
383.5€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
HLA Class II Histocompatibility Antigen Gamma Chain (CD74) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx016085
Tested Applications
ELISA, WB, IF/ICC, FCM
Description
CD74 Antibody is a Mouse Monoclonal against CD74.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: HLA Class II Histocompatibility Antigen Gamma Chain (CD74) Immunogen: Purified recombinant fragment of human CD74 (AA: 1-106) expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | 33.5 kDa |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC, FCM |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04233 |
| Gene ID | 972 |
| OMIM | 142790 |
| Alias | p33,CLIP,DHLAG,HLADG,Ia-GAMMA,HLA class II histocompatibility antigen gamma chain,HLA-DR antigens-associated invariant chain,Ia antigen-associated invariant chain (Ii) |
| Background | Antibody anti-CD74 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD74, also known as the invariant chain (Ii), is a type II transmembrane glycoprotein that plays a critical role in the immune system, particularly in antigen processing and presentation. CD74 is encoded by the CD74 gene and is primarily expressed on antigen-presenting cells (APCs) such as B cells, dendritic cells, and macrophages, although it is also found on some non-immune cells, including certain epithelial and cancer cells. One of its central functions is to act as a chaperone for major histocompatibility complex class II (MHC-II) molecules, ensuring the proper folding, trafficking, and peptide loading of MHC-II, which is essential for the presentation of antigens to CD4+ T cells. In addition to its role in antigen presentation, CD74 also functions as a receptor for macrophage migration inhibitory factor (MIF), which modulates inflammatory responses and cell survival pathways.
Productos relacionados
HLA Class II Histocompatibility Antigen Gamma Chain (CD74) Antibody
CD74 Antibody is a Rabbit Polyclonal antibody against CD74. The protein encoded by this gene associates with class II ma…
Ver producto HLA Class II Histocompatibility Antigen Gamma Chain (CD74) Antibody
CD74 Antibody is a Mouse Monoclonal against CD74.…
Ver producto HLA Class II Histocompatibility Antigen Gamma Chain (CD74) Antibody (Biotin)
H-2 class II histocompatibility antigen gamma chain Antibody (Biotin) is a Rabbit Polyclonal antibody against H-2 class …
Ver producto