HLA Class II Histocompatibility Antigen Gamma Chain (CD74) Antibody (PE)
117€ (20 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
HLA Class II Histocompatibility Antigen Gamma Chain (CD74) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx228655
tested applications
FCM
Description
CD74 Antibody (PE) is a Human Monoclonal Antibody against CD74.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | HLA Class II Histocompatibility Antigen Gamma Chain (CD74) |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG1 |
| Size 1 | 20 tests |
| Size 2 | 100 tests |
| Size 3 | 200 tests |
| Tested Applications | FCM |
| Buffer | PBS with 0.05% Proclin300, 1% BSA. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P04233 |
| Gene ID | 972 |
| Alias | p33,CLIP,DHLAG,HLADG,Ia-GAMMA,HLA class II histocompatibility antigen gamma chain,HLA-DR antigens-associated invariant chain,Ia antigen-associated invariant chain (Ii) |
| Background | Antibody anti-CD74 |
| Status | RUO |
Descripción
CD74, also known as the invariant chain (Ii), is a type II transmembrane glycoprotein that plays a critical role in the immune system, particularly in antigen processing and presentation. CD74 is encoded by the CD74 gene and is primarily expressed on antigen-presenting cells (APCs) such as B cells, dendritic cells, and macrophages, although it is also found on some non-immune cells, including certain epithelial and cancer cells. One of its central functions is to act as a chaperone for major histocompatibility complex class II (MHC-II) molecules, ensuring the proper folding, trafficking, and peptide loading of MHC-II, which is essential for the presentation of antigens to CD4+ T cells. In addition to its role in antigen presentation, CD74 also functions as a receptor for macrophage migration inhibitory factor (MIF), which modulates inflammatory responses and cell survival pathways.
Related Products
Human CD74 (HLA class II histocompatibility antigen gamma chain) ELISA Kit
Ver Producto
Human Anti-CD74 (HLA class II histocompatibility antigen gamma chain) antibody ELISA Kit
Ver Producto