HLA Class II Histocompatibility Antigen Gamma Chain (CD74) Antibody (AF488)
208€ (20 tests)
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Name
HLA Class II Histocompatibility Antigen Gamma Chain (CD74) Antibody (AF488)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx228661
Tested Applications
FCM
Description
CD74 Antibody (AF488) is a Human Monoclonal Antibody against CD74.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: HLA Class II Histocompatibility Antigen Gamma Chain (CD74) |
| Host | Mouse |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 495/520 |
| Clonality | Monoclonal |
| Conjugation | AF488 |
| Isotype | IgG1 |
| Size 1 | 20 tests |
| Size 2 | 100 tests |
| Size 3 | 200 tests |
| Tested Applications | FCM |
| Buffer | PBS with 0.05% Proclin300, 1% BSA. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P04233 |
| Gene ID | 972 |
| Alias | p33,CLIP,DHLAG,HLADG,Ia-GAMMA,HLA class II histocompatibility antigen gamma chain,HLA-DR antigens-associated invariant chain,Ia antigen-associated invariant chain (Ii) |
| Background | Antibody anti-CD74 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD74, also known as the invariant chain (Ii), is a type II transmembrane glycoprotein that plays a critical role in the immune system, particularly in antigen processing and presentation. CD74 is encoded by the CD74 gene and is primarily expressed on antigen-presenting cells (APCs) such as B cells, dendritic cells, and macrophages, although it is also found on some non-immune cells, including certain epithelial and cancer cells. One of its central functions is to act as a chaperone for major histocompatibility complex class II (MHC-II) molecules, ensuring the proper folding, trafficking, and peptide loading of MHC-II, which is essential for the presentation of antigens to CD4+ T cells. In addition to its role in antigen presentation, CD74 also functions as a receptor for macrophage migration inhibitory factor (MIF), which modulates inflammatory responses and cell survival pathways.
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