Histamine Receptor H1 (HRH1) Antibody
442€ (200 µl)
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name
Histamine Receptor H1 (HRH1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431337
tested applications
P-ELISA, IHC, IF/ICC, FCM
Description
Histamine Receptor H1 Antibody is a Goat Polyclonal antibody against Histamine Receptor H1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Histamine Receptor H1 (HRH1) Immunogen: abx269745 - C-Terminus: CNENFKKTFKRILH |
| Host | Goat |
| Reactivity | Human, Rat |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000, IHC: 4 µg/ml, IF/ICC: 10 µg/ml, FCM: 10 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, IHC, IF/ICC, FCM |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 3269, 15465, 24448 |
| NCBI Accession | NP_000852.1, NP_001091681.1, NP_001091682.1, NP_001091683.1 |
| Alias | HRH1,H1R,HH1R,Hisr,H1-R,hisH1 |
| Background | Antibody anti-HRH1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
HRH1 is a G protein-coupled receptor activated by histamine, a biogenic amine involved in allergic responses, inflammation, and neurotransmission. HRH1 is widely expressed in smooth muscle cells, endothelial cells, and the central nervous system. Upon activation, HRH1 couples to Gq/11 proteins, leading to activation of phospholipase C (PLC), calcium mobilization, and protein kinase C (PKC) signaling. In peripheral tissues, HRH1 mediates allergic and inflammatory responses by inducing vasodilation, increased vascular permeability, and smooth muscle contraction, contributing to symptoms like itching, bronchoconstriction, and edema. In the central nervous system, HRH1 modulates wakefulness, appetite regulation, and cognition. Dysregulation of HRH1 is associated with allergic conditions, including rhinitis, urticaria, and asthma. HRH1 antagonists, such as antihistamines, are widely used to treat allergic reactions and inflammatory conditions. HRH1 also plays roles in neuroinflammation and psychiatric disorders like anxiety and schizophrenia, where altered histamine signaling disrupts neurological balance.
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