Histamine H4 Receptor (HRH4) Antibody
780€ (1 ml)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Histamine H4 Receptor (HRH4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx176847
tested applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Histamine H4 Receptor (HRH4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | HRH4,GPCR105,HH4R,H4R,AXOR35, BG26,GPRv53 |
| Background | Antibody anti-HRH4 |
| Status | RUO |
Descripción
HRH4 is a G protein-coupled receptor expressed predominantly in immune cells, such as mast cells, eosinophils, basophils, and T cells, where it regulates inflammatory and immune responses. HRH4 couples to Gi/o proteins, reducing cAMP levels and modulating calcium signaling, which influences chemotaxis, cytokine release, and immune cell activation. HRH4 plays a critical role in allergic inflammation, autoimmune diseases, and chronic inflammatory conditions, including asthma, dermatitis, and rheumatoid arthritis. Its activation enhances histamine-mediated recruitment of immune cells to inflammatory sites, amplifying the immune response. In addition to its role in peripheral tissues, HRH4 is expressed in the central nervous system, where it may modulate neuroinflammation and immune cell interactions. HRH4 antagonists are being investigated as potential therapeutics for inflammatory diseases, allergic disorders, and immune-mediated pathologies. Given its role in histamine-driven immune responses, HRH4 represents a promising target for modulating inflammation and improving outcomes in allergic and chronic inflammatory conditions.
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