Histamine H2 Receptor (HRH2) Antibody
221€ (50 µg)
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Name
Histamine H2 Receptor (HRH2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx324359
Tested Applications
ELISA, WB, IF/ICC
Description
HRH2 Antibody is a Rabbit Polyclonal against HRH2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Histamine H2 Receptor (HRH2) Immunogen: Synthesized peptide derived from the Internal region of human Histamine H2 Receptor. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/5000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P25021 |
| Gene ID | 3274 |
| Alias | HRH2,gastric receptor I,H2R,HH2R |
| Background | Antibody anti-HRH2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
HRH2 is a G protein-coupled receptor activated by histamine, primarily expressed in gastric parietal cells, smooth muscle cells, and immune cells. HRH2 couples to Gs proteins, activating adenylyl cyclase, increasing cAMP levels, and promoting protein kinase A (PKA)-mediated signaling. In the stomach, HRH2 regulates gastric acid secretion by stimulating parietal cells, making it a key target for managing acid-related disorders such as gastroesophageal reflux disease (GERD) and peptic ulcers. HRH2 also plays roles in immune regulation, where its activation suppresses pro-inflammatory cytokine production and modulates T-cell responses. In the cardiovascular system, HRH2 induces vasodilation and regulates heart rate. Dysregulation of HRH2 contributes to hyperacidity, gastric ulcers, and inflammatory diseases. HRH2 antagonists, such as ranitidine and famotidine, are widely used as acid-suppressive therapies. HRH2 also has a role in cancer progression, where its expression influences tumor cell proliferation and immune evasion, particularly in gastrointestinal cancers.
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