High Mobility Group Protein B1 (HMGB1) Antibody
377€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
High Mobility Group Protein B1 (HMGB1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx240181
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
High Mobility Group Protein B1 (HMGB1) Antibody is a Mouse monoclonal antibody for the detection of High Mobility Group Protein B1 (HMGB1).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: High Mobility Group Protein B1 (HMGB1) Immunogen: High Mobility Group Protein B1 (HMGB1) |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | Observed MW: 25 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C for up to 1 year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09429 |
| Gene ID | 3146 |
| OMIM | 163905 |
| Alias | HMG1,HMG3,HMG-1,SBP-1,Amphoterin |
| Background | Antibody anti-HMGB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
HMGB1 is a non-histone nuclear protein involved in DNA repair, replication, and transcriptional regulation, but it also functions as a damage-associated molecular pattern (DAMP) protein when released extracellularly Upon cellular stress or necrosis, HMGB1 is actively secreted or passively released, triggering immune responses by interacting with receptors such as RAGE and TLR4 HMGB1 is critical in mediating inflammation, immune activation, and tissue injury, playing roles in diseases like sepsis, autoimmune disorders, and cancer It promotes cell migration, angiogenesis, and tumor progression, while dysregulated HMGB1 signaling is linked to chronic inflammation and metastasis Targeting HMGB1 holds therapeutic promise for modulating immune responses in inflammatory diseases, neurodegeneration, and cancer
Productos relacionados
High Mobility Group Protein B1 (HMGB1) Antibody
HMGB1 Antibody is a Rabbit Polyclonal antibody against HMGB1. High mobility group protein B1 (HMGB1) belongs to a family…
Ver producto
High Mobility Group Protein B1 (HMGB1) Antibody
High Mobility Group Protein B1 (HMGB1) Antibody is a Rabbit Polyclonal antibody for the detection of HMGB1.…
Ver producto
High Mobility Group Protein B1 (HMGB1) Antibody
Rabbit polyclonal antibody against HMGB1 protein. Immunogen region is Internal.…
Ver producto