High Mobility Group Protein B1 (HMGB1) Antibody
357.5€ (100 µg)
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935106861
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name
High Mobility Group Protein B1 (HMGB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx038458
tested applications
ELISA, WB
Description
Mouse Polyclonal against the HMGB1 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | High Mobility Group Protein B1 (HMGB1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_002128 |
| Alias | HMG1,HMG3,HMG-1,SBP-1,Amphoterin |
| Background | Antibody anti-HMGB1 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
HMGB1 is a non-histone nuclear protein involved in DNA repair, replication, and transcriptional regulation, but it also functions as a damage-associated molecular pattern (DAMP) protein when released extracellularly Upon cellular stress or necrosis, HMGB1 is actively secreted or passively released, triggering immune responses by interacting with receptors such as RAGE and TLR4 HMGB1 is critical in mediating inflammation, immune activation, and tissue injury, playing roles in diseases like sepsis, autoimmune disorders, and cancer It promotes cell migration, angiogenesis, and tumor progression, while dysregulated HMGB1 signaling is linked to chronic inflammation and metastasis Targeting HMGB1 holds therapeutic promise for modulating immune responses in inflammatory diseases, neurodegeneration, and cancer
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