High Mobility Group Protein B1 Acetyl-Lys12 (HMGB1 AcK12) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
High Mobility Group Protein B1 Acetyl-Lys12 (HMGB1 AcK12) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx327328
tested applications
ELISA, WB
Description
Acetyl-HMGB1 (K12) Antibody is a Rabbit Polyclonal against Acetyl-HMGB1 (K12).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | High Mobility Group Protein B1 Acetyl-Lys12 (HMGB1 AcK12) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09429 |
| Gene ID | 3146 |
| Alias | HMG1,HMG3,HMG-1,SBP-1,Amphoterin |
| Background | Antibody anti-HMGB1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
HMGB1 is a non-histone nuclear protein involved in DNA repair, replication, and transcriptional regulation, but it also functions as a damage-associated molecular pattern (DAMP) protein when released extracellularly Upon cellular stress or necrosis, HMGB1 is actively secreted or passively released, triggering immune responses by interacting with receptors such as RAGE and TLR4 HMGB1 is critical in mediating inflammation, immune activation, and tissue injury, playing roles in diseases like sepsis, autoimmune disorders, and cancer It promotes cell migration, angiogenesis, and tumor progression, while dysregulated HMGB1 signaling is linked to chronic inflammation and metastasis Targeting HMGB1 holds therapeutic promise for modulating immune responses in inflammatory diseases, neurodegeneration, and cancer
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