High Affinity Nerve Growth Factor Receptor (NTRK1) Antibody
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Description
TRKA (also known as NTRK1) is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in the TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | High Affinity Nerve Growth Factor Receptor (NTRK1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04629 |
| Alias | MTC,TRK,TRK1,TRKA,rk-A,p140-TrkA,Tyrosine kinase receptor A,TRK1-transforming tyrosine kinase protein,Neurotrophic tyrosine kinase receptor type 1,High affinity nerve growth factor receptor |
| Background | Antibody anti-NTRK1 |
| Status | RUO |
Descripción
Neurotrophic receptor tyrosine kinase 1 (NTRK1) is an essential receptor that binds with nerve growth factor (NGF), initiating critical signaling cascades required for the survival, differentiation, and functional maintenance of neurons, particularly within the peripheral nervous system. Beyond supporting neuronal growth, NTRK1 contributes to injury responses, helping facilitate neuronal repair and regeneration. Dysregulation or mutations in NTRK1 have been implicated in neurodegenerative diseases, such as Charcot-Marie-Tooth disease, as well as in certain cancers, making it a significant target for therapeutic research and drug development efforts.
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NTRK1 (pS791) Antibody is a Rabbit Polyclonal antibody against NTRK1 (pS791). This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
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