Guanine Nucleotide Exchange Factor VAV2 (VAV2) Cell ELISA Kit
513.5€ (96 tests)
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935106861
info@markelab.com
name
Guanine Nucleotide Exchange Factor VAV2 (VAV2) Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595618
tested applications
ELISA
Description
VAV2 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Guanine Nucleotide Exchange Factor VAV2 (VAV2) |
| Reactivity | Human, Mouse |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P52735 |
| Gene ID | 7410 |
| OMIM | 600428 |
| Alias | VAV-2 |
| Background | Elisa kits for VAV2 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
VAV2 is a ubiquitously expressed guanine nucleotide exchange factor (GEF) that activates Rho family GTPases, including Rac1, RhoA, and Cdc42, to regulate cytoskeletal dynamics, cell migration, and intracellular signaling pathways. Unlike VAV1, VAV2 functions in both hematopoietic and non-hematopoietic cells, where it plays roles in integrin signaling, epithelial cell polarity, and vascular development. VAV2 is activated downstream of receptor tyrosine kinases (RTKs) and integrins, linking extracellular cues to actin cytoskeleton remodeling and cell adhesion processes. Dysregulation of VAV2 is implicated in cancer progression, where it promotes cell invasion, metastasis, and epithelial-mesenchymal transition (EMT) by activating Rac1 signaling. Knockout studies reveal defects in vascular development, impaired epithelial integrity, and reduced cell migration, underscoring its role in cytoskeletal reorganization, integrin signaling, and tissue homeostasis.
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