anti- VAV2 antibody
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935106861
info@markelab.com
name
anti- VAV2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09378
tested applications
ELISA, WB, IHC, IP
Description
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly(By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | vav 2 guanine nucleotide exchange factor |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200；IF: 1:20-1:200; IP: 1:500-1:5000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 100 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P52735 |
| Gene ID | 7410 |
| Alias | VAV-2 |
| Background | Antibody anti-VAV2 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
VAV2 is a ubiquitously expressed guanine nucleotide exchange factor (GEF) that activates Rho family GTPases, including Rac1, RhoA, and Cdc42, to regulate cytoskeletal dynamics, cell migration, and intracellular signaling pathways. Unlike VAV1, VAV2 functions in both hematopoietic and non-hematopoietic cells, where it plays roles in integrin signaling, epithelial cell polarity, and vascular development. VAV2 is activated downstream of receptor tyrosine kinases (RTKs) and integrins, linking extracellular cues to actin cytoskeleton remodeling and cell adhesion processes. Dysregulation of VAV2 is implicated in cancer progression, where it promotes cell invasion, metastasis, and epithelial-mesenchymal transition (EMT) by activating Rac1 signaling. Knockout studies reveal defects in vascular development, impaired epithelial integrity, and reduced cell migration, underscoring its role in cytoskeletal reorganization, integrin signaling, and tissue homeostasis.
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