GSK3 alpha (Phospho-Ser21) Antibody

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Rabbit polyclonal antibody against GSK3 alpha protein. Immunogen region is N-terminal. Specificity is as follows for the reactive species: H:S21, M:S21, R:S21.
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | GSK3 alpha |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Recommended Dilution | WB: 1/500 - 1/3000, IHC: 1/50 - 1/100, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
Size 1 | 10 µg |
Size 2 | 100 µg |
Size 3 | 200 µg |
Size 4 | 300 µg |
Size 5 | 1 mg |
Form | Liquid |
Tested Applications | ELISA, WB, IHC, IP |
Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | P49840 |
Background | Antibody anti-GSK3 |
Status | RUO |
Note | Concentration: 1 mg/ml - |
Descripción
Related Products

Glycogen Synthase Kinase 3 Beta Phospho-Ser9 (GSK3B pS9) Antibody
Glycogen Synthase Kinase 3 Beta Phospho-Ser9 (GSK3B pS9) Antibody is a Rabbit Polyclonal antibody against Glycogen Synthase Kinase 3 Beta Phospho-Ser9 (GSK3B pS9). The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Ver Producto
GSK3 alpha Antibody
Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily, GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
Ver Producto
GSK3 alpha (Phospho-Ser21) Antibody
Rabbit polyclonal antibody against GSK3 alpha protein. Immunogen region is N-terminal. Specificity is as follows for the reactive species: H:S21, M:S21, R:S21.
Ver Producto