Growth Factor Receptor Bound Protein 2 (GRB2) Antibody
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Pida mas información
935106861
info@markelab.com
Precio
292.5€ (80 µl)
Antibody anti-GRB2
proveedor
Abbexareference
abx032778Tested Applications
ELISA, WB, IHCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
GRB2 binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences.
Background
GRB2 is an adaptor protein that links receptor tyrosine kinases (RTKs) to downstream signaling pathways, including Ras/MAPK and PI3K/Akt. It consists of one SH2 domain flanked by two SH3 domains, enabling it to interact with phosphorylated tyrosines and proline-rich regions of target proteins. GRB2 primarily binds to proteins like SOS (a Ras GEF), Shc, and PLCγ, facilitating Ras activation and subsequent signaling for cell growth, proliferation, and differentiation. GRB2 is essential for embryonic development, cellular homeostasis, and immune responses. Dysregulation of GRB2 contributes to oncogenesis, particularly in breast, lung, and gastric cancers, where it enhances cell proliferation and survival through constitutive Ras signaling. GRB2 also plays roles in immune cell signaling, particularly T-cell receptor activation and cytokine production. Knockout models demonstrate embryonic lethality, highlighting its critical function in cellular signaling and development.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Growth Factor Receptor Bound Protein 2 (GRB2)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purification
Purified Rabbit Polyclonal Antibody.
recommended dilution
WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
GRB2
dry ice
No
availability
Shipped within 5-10 working days.
alias
ASH, EGFRBP-Grb3-3, MST084, MSTP084, NCKAP2
uniprot id
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