GRB2-related adapter protein (GRAP) Antibody (HRP)
260€ (50 µl)
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Name
GRB2-related adapter protein (GRAP) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx346095
Tested Applications
ELISA
Description
GRB2-related adapter protein (GRAP) Antibody (HRP) is a Rabbit Polyclonal antibody conjugated to HRP for the detection of Human GRAP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: GRB2-related adapter protein (GRAP) Immunogen: Recombinant Human GRB2-related adapter protein (1-217 AA) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purification | Purified by antigen affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13588 |
| Gene ID | 10750 |
| Alias | GRAP, GRB2-related adaptor protein, GRB2 related adaptor protein, DFNB114 |
| Background | Antibody anti-GRAP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
GRAP is an adaptor protein similar to GRB2, containing SH2 and SH3 domains that mediate protein-protein interactions between receptor tyrosine kinases and intracellular signaling molecules. It is primarily expressed in hematopoietic and immune cells, where it plays a critical role in T-cell receptor (TCR) and cytokine receptor signaling pathways, including MAPK/ERK, JNK, and calcium mobilization cascades. GRAP functions as a scaffold protein, recruiting signaling molecules like SOS, PLCγ, and SHC to facilitate pathways that regulate cell proliferation, survival, and differentiation. It supports immune cell activation, lymphocyte development, and adaptive immune responses. Dysregulation of GRAP impairs immune signaling, leading to defects in T-cell activation, cytokine production, and immune homeostasis. It is particularly important in balancing immune responses to prevent overactivation or immunodeficiency. Knockout studies emphasize its role in TCR signaling, showing defects in T-cell proliferation and response to antigenic stimulation.
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