GRB2 Associated Binding Protein 1 Phospho-Tyr627 (GAB1 pY627) Antibody
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Description
GAB1 (pY627) Antibody is a Rabbit Polyclonal against GAB1 (pY627).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | GRB2 Associated Binding Protein 1 Phospho-Tyr627 (GAB1 pY627) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr627 |
| Recommended Dilution | WB: 1/500 - 1/1000, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13480 |
| Gene ID | 2549 |
| Alias | GRB2-associated binder 1,DFNB53 |
| Background | Antibody anti-GAB1 |
| Status | RUO |
Descripción
GAB1 is an adaptor protein involved in signal transduction downstream of receptor tyrosine kinases, such as EGFR, FGFR, and MET. It serves as a scaffold for proteins like PI3K, SHP2, and PLCγ, modulating pathways including PI3K/Akt, MAPK/ERK, and JAK/STAT. GAB1 is essential for processes like cell growth, survival, migration, and differentiation, particularly during embryonic development and organogenesis. It plays a key role in epithelial tissue morphogenesis, angiogenesis, and liver regeneration. Dysregulation of GAB1 contributes to cancer progression by enhancing cell proliferation, survival, and metastasis, particularly in liver, breast, and gastric cancers. Knockout models reveal developmental defects in the heart, liver, and placenta, demonstrating its importance in embryonic viability and tissue formation.
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