GRB2 Associated Binding Protein 1 Phospho-Tyr627 (GAB1 pY627) Antibody
221€ (50 µg)
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Name
GRB2 Associated Binding Protein 1 Phospho-Tyr627 (GAB1 pY627) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx326266
Tested Applications
ELISA, WB
Description
GAB1 (pY627) Antibody is a Rabbit Polyclonal against GAB1 (pY627).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: GRB2 Associated Binding Protein 1 Phospho-Tyr627 (GAB1 pY627) Immunogen: Synthesized peptide derived from human Gab 1 around the phosphorylation site of Y627. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Monkey |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13480 |
| Gene ID | 2549 |
| Alias | GRB2-associated binder 1,DFNB52 |
| Background | Antibody anti-GAB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
GAB1 is an adaptor protein involved in signal transduction downstream of receptor tyrosine kinases, such as EGFR, FGFR, and MET. It serves as a scaffold for proteins like PI3K, SHP2, and PLCγ, modulating pathways including PI3K/Akt, MAPK/ERK, and JAK/STAT. GAB1 is essential for processes like cell growth, survival, migration, and differentiation, particularly during embryonic development and organogenesis. It plays a key role in epithelial tissue morphogenesis, angiogenesis, and liver regeneration. Dysregulation of GAB1 contributes to cancer progression by enhancing cell proliferation, survival, and metastasis, particularly in liver, breast, and gastric cancers. Knockout models reveal developmental defects in the heart, liver, and placenta, demonstrating its importance in embryonic viability and tissue formation.
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