GRB2 Associated Binding Protein 1 (GAB1) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
GAB1 Antibody is a Rabbit Polyclonal against GAB1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | GRB2 Associated Binding Protein 1 (GAB1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/5000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13480 |
| Gene ID | 2549 |
| Alias | GRB2-associated binder 1,DFNB37 |
| Background | Antibody anti-GAB1 |
| Status | RUO |
Descripción
GAB1 is an adaptor protein involved in signal transduction downstream of receptor tyrosine kinases, such as EGFR, FGFR, and MET. It serves as a scaffold for proteins like PI3K, SHP2, and PLCγ, modulating pathways including PI3K/Akt, MAPK/ERK, and JAK/STAT. GAB1 is essential for processes like cell growth, survival, migration, and differentiation, particularly during embryonic development and organogenesis. It plays a key role in epithelial tissue morphogenesis, angiogenesis, and liver regeneration. Dysregulation of GAB1 contributes to cancer progression by enhancing cell proliferation, survival, and metastasis, particularly in liver, breast, and gastric cancers. Knockout models reveal developmental defects in the heart, liver, and placenta, demonstrating its importance in embryonic viability and tissue formation.
Related Products
anti- GAB1 antibody
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
Ver Producto
GRB2-Associated-Binding Protein 1 (GAB1) Antibody
GAB1 Antibody is a Rabbit Polyclonal antibody against GAB1. The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
Ver Producto
GRB2-Associated-Binding Protein 1 (GAB1) Antibody
GRB2-Associated-Binding Protein 1 (GAB1) Antibody is a Rabbit Polyclonal antibody for the detection of GAB1.
Ver Producto