Glutamate Dehydrogenase 1, Mitochondrial (GLUD1) Antibody
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Description
Glutamate Dehydrogenase 1, Mitochondrial (GLUD1) Antibody is a Rabbit polyclonal antibody for the detection of Human Glutamate Dehydrogenase 1, Mitochondrial (GLUD1).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Glutamate Dehydrogenase 1, Mitochondrial (GLUD1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P00367 |
| Gene ID | 2746 |
| NCBI Accession | NP_001305829.1 |
| Background | Antibody anti-GLUD1 |
| Status | RUO |
Descripción
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GLUD1 antibody
This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.
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