Gastrin Releasing Peptide Receptor (GRPR) Antibody
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Description
GRPR Antibody is a Rabbit Polyclonal against GRPR.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Gastrin Releasing Peptide Receptor (GRPR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/200 - 1/500, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P30550 |
| Gene ID | 2925 |
| Alias | GRPR,BB2 receptor,GRP-R,BB2,GRP-preferring bombesin receptor,Gastrin-releasing peptide receptor,gastrin-releasing peptide receptor,BB2R,BRS2 |
| Background | Antibody anti-GRPR |
| Status | RUO |
Descripción
Gastrin Releasing Peptide Receptor (GRPR) is another GPCR within the bombesin-like receptor family that binds gastrin-releasing peptide (GRP). GRPR is expressed in the gastrointestinal tract, pancreas, and the central nervous system (CNS). In the gastrointestinal system, GRPR regulates gastric acid secretion and promotes pancreatic enzyme release, playing a vital role in digestion. It also enhances intestinal smooth muscle contraction, facilitating gastrointestinal motility. In the CNS, GRPR is involved in memory formation and fear conditioning, as it modulates pathways in the amygdala and hippocampus. Additionally, GRPR regulates feeding behavior and satiety, influencing energy homeostasis and food intake. GRPR signaling has garnered significant interest in oncology because it is overexpressed in several cancers, including prostate cancer, small cell lung cancer (SCLC), and gastrointestinal malignancies. Activation of GRPR stimulates tumor growth, cell proliferation, and angiogenesis, making it a key target for cancer diagnostics and therapeutics. Furthermore, GRPR has roles in pruritus (itch sensation), where it modulates spinal cord circuits related to itch and pain perception. Its multifaceted roles in neurobiology, digestion, and oncology position GRPR as a promising candidate for the development of novel treatments for metabolic disorders, neurological conditions, and cancer.
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